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The lack of head-to-head comparative studies of BBFC and other IOP-lowering monotherapies and fixed-combination medications prevents the assessment of BBFC tolerability in terms of other IOP-lowering therapies, and differences in study design preclude direct comparisons between IOP-lowering medications evaluated in different clinical trials.

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Although specific drug-drug interactions studies have not been conducted with MIRVASO topical gel, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anaesthetics) should be considered.

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Alpha-2 agonists: In 30 patients with a mean age of 10 years, brimonidine treatment was associated with a mean reduction of IOP by 7%.

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